Even a pilot wouldn't say the word takeoff, it would be 'ready for departure'.
To me the main issue is not "wait" vs "hold"... it's that either way, pilots may misremember having been issues the takeoff clearance. The best defense against this, IMHO, is ground radar to detect the movement as early as possible.
[1]: https://www.faa.gov/airports/runway_safety/resources/luaw
No aircraft should ever be sitting still on a runway blind to landing traffic behind them. The time saved by eliminating the short taxi from the hold short line to the runway is not worth the additional risk incurred, either the risk of taxiing to position and failing to hold, or taxiing to position and holding while you get rearended by a landing aircraft.
The time saved is most definitely required for certain airports to maintain their current traffic levels. So we would need a study to understand if the economic impact of the reduced traffic from eliminating line up and wait is worth the expected reduction in accidents.