These aren't "tiny wins". These are massive advancements in cancer treatment. And they're happening every decade or so, and added together is drastically changing outcomes.
This is one study.
"Cancer mortality decreased by 20.1% (95% uncertainty interval [UI], 18.2%-21.4%) between 1980 and 2014, from 240.2 (95% UI, 235.8-244.1) to 192.0 (95% UI, 188.6-197.7) deaths per 100 000 population."
Childhood cancer (mostly Leukemia) treatment in the USA is a well-organized country-wide clinical study aimed, at this point, at carefully reducing the amount of high-intensity chemo via replacing it with drugs like the one in the article, Blina.
They have gotten so good at treating Leukemia that they are now optimizing for reducing the long-term negative health impacts that come as a result of the treatment.
There are still tragic cases where the patients systems don't respond well, or there are complications as a result of compromised immune systems, but everything I have experienced points to major advancements and continued progress towards improving outcomes.
Also if you think there’s no sense of urgency, you haven’t talked to anyone actually in the field. Do you really think oncologists (pediatric oncologists!) aren't eager to cure their patients?
Even historic improvements for large demographics have massive returns. Keytruda (major oncology improvement) had more than $20 billion sales in 2023.
It is hard to think of a stronger market incentive to improve drugs as much as possible.
Don’t be bloody ridiculous.
Ok, can you explain what you meant by this?
If we could find and repair DNA errors in normal cells, we could do it in cancerous cells as well. I don't think there's much of a difference.
I glean from many non-main stream sources (who are generally labeled quacks or naysayers, I have lost track of sources) :
- There have been almost no improvements in cancer treatments especially chemotherapy for _several_decades. Some sleight of hand involving some statistics and the fact that cancer can now be diagnosed in an at an earlier stage, means that the survival rate that is calculated by the survival of people Beyond 5 years of the first diagnosis, is higher.
- The primary approach to treating cancer (especially with chemotherapy and radiation) appears flawed. Cancer is a systemic disease so even if you destroy the tumor, you will have more of those propping up, because the body is already predisposed to creating them.
- It's a money making scam ( just like any other industry) that thrives in keeping a patient as sick as possible for as long as possible
-A lot of naive, but well intention people fall for the above three points mentioned.
Of course any attempt to even mention that people could be wrong would be retaliated with: you don't-care-for-people-dying response. Heroics generally trumps common sense
I really want to do whole-body clonal work. Our bodies and genes are machines, yet we still haven't put them to work. We're plastering over the breaks with crude tools that feel like modern day bloodletting. The blast radius in the transduction pathways is huge and imprecise.
I've written extensively about this topic on HN. Give me a minute and I'll dig up some references.
Edit:
https://news.ycombinator.com/item?id=35321368
Actual cancer treatments are moving forward at a good pace. Immunotherapies are a good example. Cancer treatment is an example of medical research working well.
Not to mention issue of patient being weakened by, say, organ failure, to even survive such procedure.
You didn't "write extensively", you put science fiction plots ideas that have already been done a dozen times into comments.
I'm going to go out on a limb and say that execution might be a bigger factor than ideas here.
I originally posted a follow-up message, but I revealed to much of the path gradient to build this and so I deleted it. There are so many low-hanging fruit markets, but I have to hold my tongue. It needs the right leadership and angle of attack.
I bet my reputation that none of this is science fiction, though, and I can't wait to prove you wrong about everything you doubt me on. Give me ten years on this one. I'll show you.
The Hollywood thread you keep doubting me on is going to be extremely obvious in about six months. I really want to see you eat your hat on that one. I'm sleeping on the floor every night to make it happen, and we're getting there.