Working remote showed me how much I value direct interaction with people. For me, and I spoke to a lot of people for whom it's the same, the sweet spot is a hybrid model. Three days remote, two days on-site. Sometimes the other way round, depends on the tasks for the week.

If I need to do 100% remote, because I may have a light cold and don't want to spread it, I feel miserable after two weeks. That being said, I also will never work 100% on-site again, only if I can walk to work, which given my location, will not happen in the near future.