1. Yes.

2. I don't think of the ones based on charity. The ones that come to mind are Google, Facebook, Twitter, Apple, and AOL (in its day).

My point was just that there are other ways to change the world. I used a poor and overdone example by work seemingly related to charity (how come no one is picking on the marine biology example), but you could very well have a world changing impact and be an author or a professor or a painter. Heck, you could be a mechanic or a stay-at-home mom. There's no reason changing the world has to be tied to profession at all.