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There are a multitude of supplements with clinical evidence to support their efficacy that are neither #1 nor #2. These include caffeine, ginseng, various vitamins, etc. If you go to examine.com, they analyze the strength of the studies and the effect size. Most won't have the effect size of prescription drugs but some are absolutely worth taking, particularly fish oil and vitamins like B and D.

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Caffeine and gensing have immediate onsets. You know in a small number of minutes whether you’ve had enough or too much. Vitamins usually have a wide range between enough to be useful and enough to harm you, although you’re crazy to take fat-soluble vitamins for a long period without telling your doctor and getting a blood test.

You generally have to take psych meds for quite a few days before determine their effect. If you take too little, you risk your mental health. Take too much? Have fun riding out Seratonin Syndrome!

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