Healthcare should be universal and require almost no paperwork from the patient. Our current system is too bloated and either requires a job with good insurance or weeks/months of research into your options.
Agencies like the DEA should be abolished and possession/use of drugs should not equal prison time or anything on your record. Of course, things like driving impaired are still punished because you're endangering others.
College should not be expensive or put you into debt for decades. In the US, we need a general cultural shift away from hyper individualism and unregulated capitalism.