Geeks like us love to get into SRS algorithms and chase after the 1% improvements with a cleverer repetition algorithm or a better input method. The real failure mode is much more mundane: People give up.
I see it all the time. People cram thousands of cards into Anki in their first month learning something. After a month or two they are so overwhelmed with reviews and the reviews become such a chore that they just give up. (Of course, there are people who manage to add thousands of cards every month for years and years. These are the people who would probably do nearly as well with just a pen and paper. )
Two pieces of advice that make all the difference: Make your cards a little bit 'too' easy and be rather selective with your cards.
When you first make a card you're probably actively studying the subject of the card. You're very familiar with it and it's all in your head right now. The temptation is to make a card that is fun and challenging for you right now. Resist! Instead, make a card that feels slightly too easy, so that in a week or two it will be enough to tickle your memory rather than confuse you.
Also, people dump entire books worth of sentences into Anki. I like to use the metaphor of walking through an orchard: take your time, look around and grab one or two of the nicest apples you find. If you try to grab everything you're only going to slow yourself down. Also, if you pick up a rotten apple (uninteresting/too difficult card) it pollutes your entire deck. You start to resist review your flashcards.