ProtonMail can only guarantee E2E encryption without PGP if you are sending email to another ProtonMail user. I don't know if Skiff also offers this special kind of encryption. Either way, they should be more upfront about the level of privacy they can offer.
I had a read of Skiff's page on E2EE. It is very carefully worded and, from a skim read, is not upfront about the fact that un-PGP'd email sent and received through Skiff can be read by Skiff.
https://skiff.com/blog/end-to-end-encryption-email
Oh, one more thing. Skiff's SMTP server (inbound-smtp.skiff.com) is running on AWS in the United States which means it will be beholden to US warrants. Skiff does not have a warrant canary. Getting big Crypto AG vibes from this.