I considered using something like that, but my concern that it is going to ruin my muscle memory for the situations when I cannot use it - eg locked down environments at work. So I stick to whatever can be done with standard OS capabilities.
There are some places that do not allow USB connections. People have been fired over it.
Works great on laptops and Bluetooth keyboards.
I've got a weird split thumb board like OP, and the muscle memory for a normal keyboard is fine. I think it helps that I mostly left qwerty intact, and messed with meta keys.
I'll throw another anecdote to the pile. I use a split, angled keyboard with a nonstandard keyboard layout for over a year now and I can use normal keyboards just fine.
It doesn't, I use a standard laptop keyboard and my weird-ass custom keyboard very interchangeably with zero trouble. Hell, I'm typing on a MacBook right now.
It's been a non-issue for me. I work on a standard qwerty laptop keyboard once or twice a month, but use a colemak split keyboard the rest. The worst thing that happens is I hit the wrong keys in my vim motions until my hands adjust to the standard keyboard again, but that stops happening after 5 minutes of typing.