If there are a lot of massive objects out there (rogue planets, maybe primordial black holes) then these could be used to aid acceleration and deceleration through gravity assist and the Oberth effect. (The latter describes how you get more acceleration thrusting near a massive body.)
You could fly along with an ultra sensitive gravity telescope / sensor and hop between massive objects.
You could also perhaps harvest propellant from some of these.
Long duration interstellar flight would be easier if the space between solar systems was not as empty as we think.