> There are at least three different pharmacological ways to induce hallucinations: (1) activation of dopamine D2 receptors (D2Rs) with psychostimulants, (2) activation of serotonin 5HT2A receptors (HT2ARs) with psychedelics, and (3) blockage of glutamate NMDA receptors (NMDARs) with dissociative anesthetics.

I’m always surprised when the kappa-opioid pathway (salvinorin A) is overlooked. It produces very distinctive hallucinations. I lack the personal experience to judge, but I think it’s phenomenalogically distinct from other dissociate experiences. It should be easier to research given that Salvia diviniorum and its constituents are not controlled federally nor in many states.