While layoffs are detrimental to employee morale (e.g. employees take less long-term risk), I wonder how much worse the effects of layoffs are in the creative industry.

You might be able to replace employees in a more utility-driven company. But creative people are not exactly interchangeable, as creative ideas tend to bounce better among employees who have "chemistry." These collective of creatives end up sharing tribal knowledge of producing creative outputs with a given expectation or taste. If you fire them, it will be difficult to replicate or enhance the creativity (by whatever metric we can try to measure it with).

Japanese film director Akira Kurosawa once lamented the dissolution of the studio system, which turned the industry into a loose gathering on freelancers. He believed it would be antithetical to creativity, which he sees to happen tribally.

A famous counter-example to layoffs in the creative industry is Nintendo. Former CEO Satoru Iwata opposed layoffs as a way to weather financial downturns, as layoffs would discourage employees from committing to their work in the long-term. Instead, Nintendo tries to guarantee stable employment with their sizable financial reserves, albeit not paying a high salary.

Animation studios were able to garner a sense of "expectation" and establish a brand (e.g. Pixar especially with their first 11 features) because of the "regulars" who worked on their releases. Layoffs would change the collaborative chemistry among employees, and can make it difficult to establish or maintain a brand.