I seriously doubt it. Game engines are, first and foremost, designed to provide a 2D or 3D graphics environment and input handling, they don't typically have the richness of UI components that you would expect for building a desktop app. Godot is no exception here, its UI components are very dated and limited in comparison what modern web-based applications can do. Furthermore, Godot specifically is limited to a single window (apart from popups) last I checked.

The other problem with Godot specifically is that every thing is tied to GDScript/the Godot typing system (yes, even the C# and gdextension APIs) and you need to deal with its inconsistencies. I'm currently implementing something as simple as a schema validator (think JSON schema) and it's nightmareishly tough in comparison to any other language I have implemented this in. And then we are not even talking about the almost universal lack of error handling in a large portion of the built-in functions, or really silly things like that opening a TCP connection apparently requiring active polling. I could go on.

I love Godot, it's super simple to build game-related things with, but holy macaroni do I wish they had thought things through just a little more when they implemented them. I would never want to build a data-heavy desktop app in Godot.