2,3,7,8-TCDD is one of the most toxic dioxins known.
https://www.bfr.bund.de/cm/349/harmful-compounds-might-be-fo...
Is a microscopic bit of harmful chemical going to do anything? We are exposed to lots of harmful chemicals all the time. Even our cleaning products are harmful.
https://en.wikipedia.org/wiki/The_dose_makes_the_poison
Admittedly I'm not going to go around boiling sucralose and drinking it but I'm also not going to give this much more thought either.
Dioxins are generally a class of chemical where the answer is yes. Even trace amounts are horrifically carcinogenic.
In one instance, six truckloads of 2,3,7,8-TCDD-contaminated waste (not pure TCDD) mixed into used motor oil and spread over the roads of a ~420 acre town as dust control resulted in the entire town having to be permanently evacuated and disincorporated.
https://en.wikipedia.org/wiki/Times_Beach,_Missouri
Also, more generally, letting catchphrase-driven handwaves from industry about how their dumping is actually ok really isn't a great way to be. Things like dumping of low-level waste (ie not actual uranium or fission products, just ordinary furniture/materials from facilities that are mildly activated) off the coast of california have increasingly been realized to be a mistake. Even "diluted into a whole ocean" (it never is), it turns out it doesn't just go away, and the plumes are in fact both detectable and potentially harmful.
You know what actually is the solution? The complete opposite, concentration and incineration (for dioxins) or permanent containment (high-level nuclear waste).
"Further, the team discovered that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity. ‘It’s time to revisit the safety and regulatory status of sucralose, because the evidence is mounting that it carries significant risks,’ warned Susan Schiffman, the study’s corresponding author."