But for this particular issue, the problem is a recent significant change in cancer rates. That means that the cause is likely a recent significant change. The items you listed don't strike me as having changed significantly in decades.
Off hand, I can think of dozens of environmental factors that have changed: increase in acceptance of mental health leading to more Rx for same; vaping; marijuana use; a different mix of recreational drug use; less socializing leading to less physical activity; less air pollution; less physical activity as children due to attitude changes about their safety on their own in public; and a dozen more I didn't think of.
I wish good luck to the medical professionals who need to untangle this and find the source causes.