I would think that a pre-built manufactured home delivered pre-assembled would make more sense. Pour a slab, hookups for water, and electricity, done.
The frame is the cheapest part of a permanent structure, and a 300-500sqft ADU is not going to have much in the way of plumbing, electrical, and hvac. Paying a plumber, electrician, and hvac tech for new construction on a tiny building is not going to represent a significant chunk of your budget for what amounts to 1-3 days work maximum.