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What nasty side effects do you mean?

There’s really almost none [0] with the most common diarrhea.

[0] https://en.wikipedia.org/wiki/Metformin

Not sure it qualifies as “nasty”, but performing does seem to somewhat impede expected benefits from exercise: https://peterattiamd.com/metformin-and-exercise-deja-vu-all-...

It also seems to upregulate cortisol in some cases, which is undesirable: https://pubmed.ncbi.nlm.nih.gov/27459533/

These definitely don’t seem very nasty to me. I suppose it’s good to be aware of these effects, but don’t imagine them affecting most people’s decision to take it unless they are bodybuilders or something.

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