One is a highly controlled scenario where all(most all) the externalities can be controlled. The other some extremely complex modeling, which will, at least in my view, always depend on some consensus among the participants which factors are more important than others.
I am far from a climate change skeptic, but the best example for the fundamental failure of grasping complex scenario with some factor-based prediction systems has been demonstrated with the complete failure of economics in predicting something as "simple" as the financial crisis. But then again, I am coming from a social science perspective assuming that as soon as humans are involved data and data analysis will always be subjective.