For example what audio framework will your distro use - Jack? OSS? Pulseaudio? They will have to use what Valve wants you to use, if you want to play their games. Multimonitor support ? HDMI? use the toolkits that Valve will define. I would'nt be surprised if Valve influences the switch to Wayland or something.
And the big one ? packaging format.
What I'm really hoping for - Valve being able to arm twist ATI and nVidia for better drivers (which may happen anyway because of Ivy Bridge graphics and its great linux support[1] )
This is a Good Thing. Linux has been suffering from a severe framework fragmentation which leads to a very small addressable market. Unifying behind some frameworks will undoubtedly increase that market size.
[1] www.phoronix.com/vr.php?view=17284