Those enzymes that it unregulated, those genes that they upregulate… do you know what they are? Let’s talk about one…mnSOD or SOD2.
Do you know that enzyme needs a co-factor and that co-factor is manganese. What do you think happens when you keep exercising, but do not replenish your manganese? mnSOD does not work as fast and this leads to a buildup of superoxides and disease.
Up regulating these enzymes because we’re exercising is not decreasing oxidative stress, it’s getting rid of the oxidative stress that we created. And all that results is that we deplete ourselves in manganese.
Does this happen for everyone? No does this happen for people who might have polymorphisms in there SOD2 genetics? Probably.
https://journals.physiology.org/doi/full/10.1152/ajpcell.003...