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Comment by Podgajski | Hacker News Reader

Our bodies are quite capable of dealing with when we have the right nutrition and we don’t create too much oxidative stress. I can’t believe how little understanding there is of the impact of distress.

Just being deficient in manganese, zinc and copper could increase superoxides to a point that starts creating DNA damage.

And it’s funny that you don’t think reactive oxygen species damage heart muscles. If there’s too much of them that is. If there’s an imbalance that is.

https://www.hindawi.com/journals/omcl/2020/5732956/#

If you’re not exactly sure what reactive oxygen species are, then, why don’t you look them up before you make comments of what you know nothing about. If you’re making fun, about a stupid comma that Siri placed in my sentence then well, that’s just childish. And you’re not serious at all.

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Strength training isn't the same as chronic distress though. Activity that uses muscles above current baseline leads to inflammation, which leads to hypertrophy and growth, which results in downregulation of inflammatory markers in the long term. The body upregulates anti-oxidant species in response to normal increases in oxidative stress. Yes, acute/extreme spikes in ROS generation is bad, but that's not what actually occurs in regular exercise.

Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality.

Maybe you should actually take some courses in molecular biology, instead of googling some very basic high-level articles and over-generalizing to support your misguided point.

> Tomes of papers support the connection between physical activity, reduced inflammation markers, and decreased all-cause mortality

Correlation, not causation.

What the hell is muscle use above a curent baseline? What does that even mean? I’m pretty sure you’ve never taken a science class in your life.

> What the hell is muscle use above a curent baseline? What does that even mean?

Meaning, a conservative increase over your current training regimen, as opposed to over-training. If you go from couch potato to running several miles a day, that's going to be way more stressful than gradual ramp-up. I made that caveat because intense over-training can cause really bad things such as rhabdomyolysis at the extreme.

>I’m pretty sure you’ve never taken a science class in your life.

I'm pretty sure I have a BS in chemistry and worked as a synthetic chemist for years, and you are talking out your ass.

Maybe get another degree in biology and nutritional genomics before saying anything else about human health then.

Gentle reminder that personal attacks are not permitted here.

Please remind the others in this thread of the same. Thank you. I apologize for my own behavior. It seems that this was only singled out to me for some reason.

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