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Comment by jmauritz | Hacker News Reader

That some proper deep broscience I haven’t seen in years, “oxidative stress” nice!

Here is the science. You are mentally lazy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892233/

Further, whole-body resistance exercise increased oxidative damage. For example, resistance exercise at a 10-repetition maximum load increases the MDA level in the blood [19]. Furthermore, local resistance exercise, which is a single type of resistance training in a specific muscle group, can increase oxidative damage.

Listen, the Bros don’t even talk about oxidative stress. What do you think it is that oxidants cholesterol to cause coronary artery disease? What do you think triggers the DNA changes to cause cancer?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/

You do understand that biology is complex and multifaceted, and aging/healing is more complex than "oxidative stress bad", right? The body does double/triple/n-tuple with almost every biomolecule. "Inflammation" (which isn't a single process) is widely vilified but it's absolutely necessary to grow and heal.

Of course, it’s complicated, but it’s simple as well. It’s just about Balance. Too much inflammation is bad. Too little is bad. we need just to balance them out, and it’s the same with oxidative stress. Reactive oxygen species kill pathogens but they can also kill us. We balanced them using enzymes, and these enzymes need enzymes and cofactors.

So then why are you being so contrarian? The overwhelming evidence supports the theory that a combination of strength and cardio training leads to better healthspans. And before you "correlation is not causation" yeah no duh, but the evidence is absolutely conclusive by now that exercise is better than not.

> overwhelming evidence supports the theory that a combination of strength and cardio training leads to better healthspans.

Better for who? That’s my point. Obviously my grandfather didn’t need it right?

But I’m against these simplistic explanations for something much more beautiful happening underneath all this bro science advice.

There is no evidence that strength and cardio ALONE leads to longer life and health spans. what I’m arguing is that there is something beneath what you’re all looking at that would help way more people if we understood it completely. And what that is is the balance and mitigation of oxidative stress. It is quite probable that because my grandfather did not work out, he did not create a lot of oxidative stress, and that’s what helped him live longer. What would be more important for humanity is understanding oxidative stress.

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