I also have similar single monitor (a BENQ EW3270U) set to 200% scale. I use Linux, and my productivity is good by binding F1 to F5 keys to switch to different virtual desktops.

F1 -> Terminals. (Wezterm showing 4 terminals in a 2x2 grid)

F2 -> Code editor or IDE. Sublime Text in my case.

F3 -> Internet Browser. Firefox with Container extension.

F4 -> File Manager or any other misc apps.

F5 -> unused

I'm so used to these keybindings, that when I'm on foreign computers I involuntarily find myself pressing F1 or F3 when I want to enter some command or browse some web page.