Garry Newman's Portable Workstation: A Hard Drive
garry.tv
garry.tv
It's my decades-long experience with Windows that the moment you swap an existing boot drive into a new/different PC, Windows completely shits the bed with driver mismatches and incompatible versions.
Both Linux (arch) and Windows 7 worked without a complaint when swapping hard disk between the two. I do remember that back in the days you'd get an instant blue screen as soon as you change anything important hardware related on your rig.
The only risk factor I can see is that the hard drive might get damaged during transport.
If you tried doing the same with an off-the-shelf Windows 7 upgrade install or an OEM install, I'm pretty sure you'd run into problems, though, unless the two machines were identical from the point of view of Windows Activation.
It used to be an issue in Vista days but no longer - they have relaxed most requirements.
Lack of SSD surprises me, one would think Gary Newman (creator of Garry's Mod) had need.
I don't know if a quality SSD would play well with the size of modern games.
It's the same reason I simply archive every email instead of deciding what to keep and what to trash.
I don't get what he means by this...?
I don't quite get why doesn't he use something that syncs before he reaches the office, though. Setting up the machine to power-on automatically a couple hours earlier and syncing using Dropbox, Unison, etc is not that hard.
I agree with what some others have posted about using an SSD with eSata or USB3. This really is a great way to go. I wold recommend also throwing some kind of encryption in the mix (either encrypt the hard drive or use BitLocker or something comparable withing the OS since you will no doubt be carrying sensitive data or intellectual property around.