I obviously don't mind doing thorough analysis. But this analysis can be done correctly only if you define the end goal, what you are trying to optimize.
If the goal is the prosperity of humanity then I'm all for it. However, if that's the case two things must be noted beforehand:
1) This is an anthropocentric approach. The parent comment seemed to imply that anthropocentrism is bad for some reason, so it might be an issue on your end too.
2) Prosperity of humanity as a goal is at odds with biodiversity. I don't regret the extermination of smallpox for one thing. I also appreciate for example that we largely replaced natural ecosystems with agricultural monocultures that yield more tons of food per square kilometer. This is great, we won't be able to sustain 8 billions of humans otherwise.
If you agree with these points then this means that we agree on principle. The rest are implementation details that can be figured out. E.g. your question of whether "would be healthier if they interacted differently with their environment at scale" -- probably yes, there are many things that can be improved.