The author borrows the prefix from the "eigenquestions" article linked therein, where that author defines it as
> "Eigenquestion" is a made-up-word that borrows from the linear algebra concept of eigenvectors (mathematically: represents the "most discriminating vector in a multidimensional space"). ... For a simplistic definition, the eigenquestion is the question where, if answered, it likely answers the subsequent questions as well. Great framing starts by searching for the most discriminating question of a set — the eigenquestion.
But the "most discriminating vector" idea is not really what an eigenvector is. It can be roughly thought of as that in some senses, like principal component analysis or SVD, where the term has been used to refer to a particular vector space basis formed of eigenvectors (e.g., "eigenfaces"). But in this context they authors are simplifying this to just "the most important question." The use of the fancy math jargon doesn't seem to add anything beyond this. It feels like a kind of faux intellectualism that I have learned to dislike (despite having a math PhD myself!) after hearing too many tech bro types abuse math terms beyond recognition.