This will still break DKIM (no signing for the fake second message, and even the first message's signature is going to be corrupt?), so a restrictive DMARC policy (p=reject; adkim=s) should mitigate this even if the server software is vulnerable, right?
And if someone tries to force a server to send email for an unauthorized source (e.g. make mail.example.org send a bogus mail for ycombinator.com) - well, this sucks in terms of potentially having to get the vulnerable host out of DNSBLs, but email is still not gonna get through (because of SPF) and I hope RBLs are gonna have a bit relaxed attitude towards this in the next few weeks?
(I don't seriously believe someone's not checking SPF, DKIM or DMARC those days - they're basically three cornerstones of modern mail server auth)