I didn't put a huge amount of effort into the sound isolation, the acoustic panels mainly reduce echos but do nothing for low vibrations (people walking around the house, cars idling outside, airplanes). I have total control over the lighting (I don't want to see any daylight when I'm working). It can get a little stuffy if I don't turn on the AC/fan.
Personally I love working in a little space with my back to a wall. Because of the acoustic tile, many people think I'm just in a work office. I find the limited view (basically I'm looking at a monitor with a wall right behind it) keeps me from getting distracted.