When I made the decision to go fully remote, the first obvious step was to move out of the Bay Area. One of my hard requirements was property with a separate physical building for a home office. This requirement vastly reduced the set of viable homes to choose from, vastly constrained the neighborhood choice to more rural areas, and somewhat increased the cost. But after more than a year of working this way, I have to say it was well worth it. I wouldn't want to go back to work-from-spare-bedroom or work-from-closet. If you can manage it financially and you can culturally manage to live in a more rural area, you'll won't want to go back, either.

First, and obviously, it's quiet. No more kids playing in the house chaos. It's private, and can be locked separately, so I can work on my company's confidential stuff. Economical to heat and cool, since it is a very small space. You also get that intangible "separation" of your work life from your home life that your commute used to give you--hard to explain. A brief walk outside to and from the office allows me to reset into work-mode or home-mode. Highly recommended if you can swing it!