> I don't necessarily see science as trivial pursuit because of our human limitations
Me neither, quite the opposite, but the problem you are describing has always been a problem when discussing metaphysics, as it is commonly called.
Science is aware of its limitations, that's what makes it science.
But sometimes, people tend to conflate a materialistic world view (maybe even strong determinism) with believing in the scientific method.
The "belief" I mean here is strongly tied to assigning the appropriate role in ones thinking to scientific facts.
Proving an all-encompassing scientific world view is a logical paradox.