In a Tesla, these things are in a predictable place physically and the controls respond quite nicely. I can use the scroll buttons and other buttons on the yoke to control these and various other things without taking my eyes off the traffic. There's even good voice control for things like navigation (“take me home”).
However, I've encountered some challenges with the blinker controls, particularly when the yoke isn't upright. I've gotten more accustomed to their placement and can usually find the right spot instinctively, but occasionally, they either don't respond or I press the wrong area. It's a minor but noticeable annoyance. I'm thinking about adding tactile stickers to the wheel to help identify these spots more easily.