However if you really want speed I wonder if you could bridge access to certain useful functions by delegating access to, for example, sandboxedAnimate = function (sel, attr, duration, easing) {} in a closure. If you want to allow plugins on your site for example, 200X for basic stuff and full speed for jquery animations, etc would be more than enough 99.9% of the time.
Also if you use CSS animations where there would be zero slowdown. So make that plenty fast 99.99% of the time.