What is considered the most security conscious OS today? What is the most secure OS that can be run without enormous pain?

I am about to rebuild my machine, and have been toying with switching to Qubes or Fedora Silverblue + distrobox, but would love to hear if there are better options available today.

I install so much developer tooling it seems inevitable that a bad actor can slip in and upload my $HOME. Trying to ascertain a practical way of segregating personal data from applications. I already run some apps in VMs, but trying to become a bit more rigorous about isolation.