And the short-lived LEGO Quatro brick was...you guessed it...four times larger than a regular LEGO brick. Still compatible with both other sets.
45003: Soft Starter Set https://www.rapidonline.com/45003-lego-soft-starter-set-70-1...
I had loads of fun playing with these in the lego centre (forget the kids!)
Stepping barefoot onto a Lego brick hurts, but stepping barefoot onto a Duplo brick is much worse. Those things look innocent enough, but in the dark they turn into veritable caltrops!
I've seen people use Duplo and Quatro for space-filling when they needed a large amount of structural brick somewhere that won't be seen in the final model. Think having a LEGO city setup that has an underground level.