We have at this moment countless processes happening in our bodies - cells dying and dividing, reacting to their environments, communicating amongst one another, and we are totally oblivious to nearly all of it, let alone do we experience a sensation of pleasure or pain in each of these processes.
Not all matter, not all living cells or fully formed organisms even, have the ability to experience consciousness or sense pain and pleasure any more than they automatically have the ability to see, hear, or taste.
It's all dependent on complex systems that evolved specifically to create each of those sensations, and even then on those systems functioning properly. In humans, consciousness can be totally disrupted by things like sleep or general anesthesia, disrupting any of the senses is as simple as cutting the nerves that feed these inputs into the brain or damaging the brain that is interpreting those inputs.
It seems sensible to me that we would be more wary of growing literal brains on a chip as we know for certain that brains have the capacity to produce consciousness. It's also sensible to me that we should be somewhat wary of creating that same consciousness in non-biological systems, even though we aren't yet certain whether they're capable of it.