I remember when I tried GIMP many years ago. I had many little windows scattered across my desktop, and as soon as I misclicked on my background I'd suddenly lose focus of the app and all the sub-windows (toolbar, layers, etc) would disappear.
I either had to run my mouse back to the image's window or alt-tab back to the app to regain focus.
I found this incredibly terrible as a UI approach, but found no resources explaining why this is a good thing.
When you're used to change tools via keyboard shortcut (and thus, don't need tools window most of the time), it's a great benefit.
Add to that the multi-desktop, multi-monitor aspects (although detachable docking panes can help a lot with that).
I also thought we were over mystery meat navigation, but it seems to be going strong at GIMP. Not only does having icons for each tab make it look incredibly busy, but it also makes it harder to learn and wastes a ton of screen space. I can't see a single benefit other than it doesn't look like Photoshop.
I wonder how hard it would be to redo the entire interface from scratch. I would love to design it, but no way do I want to navigate their bureaucracy.