Prisma is going to significantly improve support for edge functions soon. We are compiling our Query Engine to WASM, and have already added support for Serverless APIs from PlanetScale and Neon.

You can fill out the survey here if you'd like early access to this: https://github.com/prisma/prisma/issues/21394

We'll make some noice about this together with Supabase when it is ready, so you won't miss it :-)