Prohibition increased alcohol-related deaths and created a black-market of products so much worse than the regulated market before or after[0]. I would say that, in fact, prohibition did not work.

And neither does current drug prohibition. Fentanyl deaths are directly caused by the black-market supply of drugs in the US, and it isn't "decriminalized" cities like Portland that are leading these charts[1]. The current drug prohibition just means that the demand that will always exist is being supplied by mis-dosed poison instead of a well-regulated market like modern alcohol (and marijuana in some states).

[0] https://en.wikipedia.org/wiki/Consequences_of_Prohibition [1] https://www.cdc.gov/nchs/pressroom/sosmap/drug_poisoning_mor...