The vast majority of Desktop users just use Debian or Debian-based distros like Ubuntu, Linux Mint and so on.
So in the end, it is just a matter of whatever pre-installed software you get. It used to be that vanilla Debian was a bit hard to use but I don't think that is true anymore. (Though I still recommend Linux Mint for the absolute "just works" experience.)
For 90% of users, they are not going wrong using Debian or one of the popular Debian-based distros. After that is is basically just a matter of specialized needs.
Want to make administering your system a hobby and part of your personality? Have some Arch.
Need professional support? OpenSuse.
Need reproducible builds? Nix/Guix.
Need a minimalist distro that runts on potatoes? Puppy Linux and whatever else.
Wayland vs X11? Systemd? If you know these words, you are already way too deep in the rabbit hole.