It's been on my list to do a proper shootout of all the various new quant formats floating around (my list here: https://llm-tracker.info/books/llms/page/quantization-overvi...) but a lot of them don't have very good production code yet (eg, a few months ago, when I tried OmniQuant, some of the important bits of code wasn't even included and had to be gotten directly from the authors: https://llm-tracker.info/books/llms/page/omniquant).
If you're looking for the best widely deployed quant format atm, it's probably ExLlamaV2's EXL2 - it supports arbitrary bpw w/ a calibration file, and also 8-bit kvcache support. I haven't tested EXL2 much at lower bpws though.
Note, both llama.cpp and AirLLM allow layer offloading to system memory (or in AirLLM's case, even to disk?!).
r/LocalLlama probably is the best place to search for if you're looking for people's experiences w/ quants. I know some people have been testing, like: https://www.reddit.com/r/LocalLLaMA/comments/17klaa5/tested_...