I submitted a meme from November and asked it to explain it and it seems to be able to explain it.
Unfortunately chat links with images aren't supported yet, so the image:
the response:
The humor in the image arises from the exaggerated number of minutes (1,300,000) spent listening to “that one blonde lady,” which is an indirect and humorous way of referring to a specific artist without naming them. It plays on the annual Spotify Wrapped feature, which tells users their most-listened-to artists and songs. The exaggeration and the vague description add to the comedic effect.
and I grabbed the meme from:
https://later.com/blog/trending-memes/
Using the human word "understanding" is liable to set some people off, so I won't claim that ChatGPT-4 understands humor, but it does seem possible that it will be able to explain what the next meme is, though I'd want some human review before it pulls a Tay on us.