Not a large site, but I used django-ninja in production for internal tooling at a very large game dev/publishing company. The APIs routinely handle 1000s of calls (via an integration with Dagster) for moving large amounts of data around and into a reporting system. It's rock solid and fast. I'm on v0.22 however and need to do some refactoring to move to 1.0 because of changes to the integration with Pydantic.

It is so easy to set up and use and it's at worth giving it a spin if you're curious.