One of my Amiga's had 4 CPU families: A 6502 core on the keyboard, a Z80 on the SCSI controller, an x86 on a bridge board (the Amiga 2000 had ISA slots, and one of them was in-line with a Zorro slot so you could get a board that let you run x86 software using a window on the Amiga desktop as the output; I don't remember if the bridge board itself was an 8088 or 8086, but I upgraded it with a 286 accelerator card) and of course the 68000 (+ a 68020 expansion)....
Looks like it's this one I remember:
In that sense, the 8-bit Commodores were a bit like mainframes - one could load a data transform program to run on the floppy drive and run it without bothering the host. I believe it goes a bit further than the Atari family in that.