I donno, it hasn't been a big deal. I've worked for startups and also doing consulting work the past 20 years, I always mentioned my weird schedule when interviewing, maybe it's tech, maybe just my bubble, but it's fine. During that time I didn't tend to schedule many appointments.
Now I'm doing a different thing, trying to see if I can actually adapt to be on a 24h schedule and be a "morning person" and all that.