The second list only matters once you've checked the correct box. If you go to a .NET shop and say "I've never used Microsoft products before but I'm a quick learner, look at these haskell projects" your resume is going in the bit bucket.

with the exception being if they have some constraint that means you are the only person applying to the job, e.g. they want you onsite 5 days a week in the middle of nowhere and you're the only person willing to move out there

Often (sadly) a non technical person from HR pre filters applications.