I have first hand experience with multiple businesses ranging from smaller software houses to tech teams in huge non-tech companies - resumes without a relevant 4-year degree are simply discarded. It's automatic. There is simply never such a dearth of applications that a 4-year degree stops being a feasible first-pass for pruning the numbers down (despite how many great candidates it throws away...).

In fact, it may be the opposite - that huge tech companies are more likely to drop that requirement.