I (generally) haven't heard people saying it's impossible, but it absolutely adds friction.
at the end of the day after doing this I do feel more tired, but I get plenty of self-scheduled productive little discussions.
I still feel you're losing something without in-person (including social) interaction. I know for me personally, I would say I have much weaker connections to many people I've never met in person. That said, there are a bunch of other factors involved with building new connections as well that aren't purely about being virtual.