The most famous study is the seventh adventist study. The study in question is not tiny. About 70k people participated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191896/
https://www.sciencedirect.com/science/article/pii/S000291652...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191896/
https://www.sciencedirect.com/science/article/pii/S000291652...