We already do have a law of physics that is relevant here. We know that the information capacity of space is finite and fixed. A centimeter of space can only store so much information before it becomes a black hole. That means that to build a simulation in our universe you can only ever subdivide a fixed pie of information. That means the more relevant thing to ask is if a quantity of information is more likely to exist in the base reality or the simulated one. Because we have to assume that the base reality is not carpeted over with simulation super computers it seems safe to assume a random bit of information is more likely to be part of the base reality rather than a simulation all else being equal.
I think the idea of the universe being a simulation is just more fun