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Don't do that. It will cancel out the benefit of going up.

Can tell from experience.

:D

It's obviously much less demanding and has therefore less health benefits. If you can't climb 50 Stairs you should start exercising ASAP

It has less benefit, sure, but probably different benefits.

Running downhill is a great way to get DOMS because of the increased eccentric contraction.

Apparently the body can adapt to eccentric exercise quite quickly, to the point that DOMS and other effects like muscle damage are reduced:

make sure your knee are straight up and down, don't twist your knee going down stairs incorrectly.. it'd wear your knee out fast and unnecessarily